8. Elavil, Endep, Vanatrip (amitriptyline)
Tricyclic antidepressants like amitriptyline, are associated with weight gain than any other migraine treating drug or antidepressant. They targets the neurotransmitters, which are involved in appetite nd energy, like dopamine, serotonin, and acetylcholine but the weight changes is mainly caused by their antihistamine properties.
The overdose of these drugs can directly affect the heart so they are prohibited by the doctors to be given in depression but lower dosed of these drugs can treat migraines and also results in weight gain like more than 5% in 26 weeks.
9. Allegra (fexofenadine and pseudoephedrine)
The weight gain due to psychotic drugs is mainly caused by their antihistamine properties but these properties are absolutely unimportant for them to be beneficial.
Antihistamine activities are essential for the efficiency of drugs related to allergy. According to the studies, people who were on drugs like Zyrtec and Allegra gained 55% more weight than people who weren’t. And usually happens due to antihistamine activities caused by the drugs. When we block histamine, it may affect the brain’s function to regulate food conception process.